Role of cysteinyl-leukotrienes for portal pressure regulation and liver damage in cholestatic rat livers

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Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway. The derivation of their chemical structures and identification of their pharmacologic properties predated the cloning of their classical receptors and the development of drugs that modify their synthesis and actions. Recent studies have ...

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ژورنال

عنوان ژورنال: Laboratory Investigation

سال: 2013

ISSN: 0023-6837,1530-0307

DOI: 10.1038/labinvest.2013.115